Abstract
PURPOSE
Extramammary Paget’s disease (EMPD) is a rare but lethal intraepithelial malignancy without standardized guidelines
concerning diagnostic or therapeutic approaches. We report a case of EMPD of the scrotum treated with excellent results using high-dose brachytherapy.
METHODS AND MATERIALS
A 76-year-old male originally presented in 2015 with pruritus and erythema of the
right scrotum, biopsy proved to represent extramammary Paget’s disease. He was treated
for a year with topical creams without sustained relief. In July 2016 he underwent
a right hemiscrotectomy which revealed stage 1 EMPD of the right scrotum and the medial
thigh with positive margins but no deep invasion. Brachytherapy was selected as the
most appropriate treatment option and carried out in December 2016 using HDR with
a H.A.M. applicator and CT treatment planning.
RESULTS
On December 2021, at 5 years of clinical and pathological follow up, the patient remains
NED with minimal skin toxicity.
CONCLUSIONS
High-Dose-Rate Brachytherapy appears to be a feasible treatment alternative as adjuvant
therapy in patients with EMPD with incomplete resection.
Keywords
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References
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Article info
Publication history
Published online: December 09, 2022
Accepted:
August 15,
2022
Received in revised form:
July 20,
2022
Received:
March 21,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
