Research Article| Volume 21, ISSUE 2, P224-228, March 2022

Long term outcomes of Carcinoma Buccal Mucosa treated with High Dose Rate Interstitial Brachytherapy

  • Harjot Kaur Bajwa
    Department of Radiation Oncology, Basavatarakam Indo American, Cancer Hospital and Research Institute, Hyderabad, Telangana, India
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  • Rohith Singareddy
    Corresponding author. Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Road number 10, Banjara hills, Hyderabad 500034 Hyderabad, Telangana, India. Phone number: 9160390945; Fax: 040-2354 2120
    Department of Radiation Oncology, Basavatarakam Indo American, Cancer Hospital and Research Institute, Hyderabad, Telangana, India
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  • Alluri Krishnam Raju
    Department of Radiation Oncology, Basavatarakam Indo American, Cancer Hospital and Research Institute, Hyderabad, Telangana, India
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Published:December 04, 2021DOI:



      : To analyze the long-term local control, overall survival and toxicity in Carcinoma Buccal Mucosa patients treated with interstitial brachytherapy.


      : This analysis included patients diagnosed as Carcinoma Buccal Mucosa on biopsy and treated with radical brachytherapy or External Beam Radiotherapy (EBRT) followed by brachytherapy boost. All patients received High dose rate (HDR) interstitial brachytherapy. The total dose was 35 Gy in ten fractions for brachytherapy alone. Patients who received EBRT (50–54 Gy) were boosted by brachytherapy to a dose of 18–24 Gy in 6–8 fractions. All patients were treated using CT based planning.


      : Between 2007 to 2017, a total of 24 patients of Carcinoma Buccal Mucosa received HDR interstitial brachytherapy either alone or as a boost. Majority of the patients were tobacco chewers (80%). 17(71%) patients were clinical stage T2N0M0 and 7(29%) were clinically T1N0M0. At a median follow up of 7 years (3–12 years), the local control rate was 100% in stage I and 88% in stage II. The 5 year overall survival rate was 80%. Two patients developed nodal recurrence and one patient developed distant metastasis within two years of treatment. Tumor size and brachytherapy technique (radical vs. boost) did not impact local control or overall survival (p > 0.05). Majority of the acute toxicities were Grade 1 and 2. One patient developed osteoradionecrosis of the mandible.


      : Interstitial brachytherapy in early-stage Buccal Mucosa cancer either alone or as a boost provides excellent long term local control and overall survival. The acute and late toxicities are acceptable with majority of the patients presenting with Grade 1 or 2 toxicity.


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