Commissioning of Post-Treatment PET-Based Dosimetry Software for Hepatic Radioembolization with Yttrium-90 Microspheres

      Radioembolization via yttrium-90 (90Y) microspheres enables selective internal radiotherapy (SIRT) for hepatic malignancies. Even though careful planning of the procedure takes place, including pre-treatment angiograms and technetium-99m labeled macroaggregated albumin (99mTc-MAA) SPECT, there is no standard for post-delivery imaging and dosimetry of the microsphere distribution for treatment delivery verification. Recent studies have reported utilizing the small positron yield of 90Y (32 ppm) to image patients with PET after their treatment to perform dosimetry analysis. In this study, we compared results from a commercial dosimetry software—MIM Sureplan (MIM Software, Cleveland, OH)—to a MATLAB-based program developed in-house for the purpose of commissioning the software for clinical use.
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