Brachytherapy
Volume 8, Issue 1 , Pages 26-33 , January 2009

Phase I–II trial of perioperative high-dose-rate brachytherapy in oral cavity and oropharyngeal cancer

  • Rafael Martínez-Monge

      Affiliations

    • Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • Corresponding Author InformationCorresponding author. Department of Oncology, Clínica Universitaria de Navarra, University of Navarra, Avda Pío XII s/n, Pamplona, Navarra, Spain. Tel.: +34-948-255400; fax: +34-948-255500.
    • ,
  • Alfonso Gómez-Iturriaga

      Affiliations

    • Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • ,
  • Mauricio Cambeiro

      Affiliations

    • Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • ,
  • Cristina Garrán

      Affiliations

    • Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • ,
  • Néstor Montesdeoca

      Affiliations

    • Department of Maxillofacial Surgery, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • ,
  • José Javier Aristu

      Affiliations

    • Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
    • ,
  • Juan Alcalde

      Affiliations

    • Department of Otolaryngology, Clínica Universitaria de Navarra, Pamplona, Navarra, Spain

Received 5 February 2008 ,Revised 30 June 2008 ,Accepted 6 October 2008.

References 

  1. National Comprehensive Cancer Network. Practice Guidelines in Oncology.v.2. 2007.
  2. Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937–1944
  3. Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945–1952
  4. Strnad V, Lotter M, Grabenbauer G, et al. Early results of pulsed-dose-rate interstitial brachytherapy for head and neck malignancies after limited surgery. Int J Radiat Oncol Biol Phys. 2000;46:27–30
  5. Grabenbauer GG, Rodel C, Brunner T, et al. Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997. Strahlenther Onkol. 2001;177:338–344
  6. Beitler JJ, Smith RV, Silver CE, et al. Close or positive margins after surgical resection for the head and neck cancer patient: the addition of brachytherapy improves local control. Int J Radiat Oncol Biol Phys. 1998;40:313–317
  7. Lapeyre M, Peiffert D, Hoffstetter S, et al. Post-operative brachytherapy: a prognostic factor for local control in epidermoid carcinomas of the mouth floor. Eur J Surg Oncol. 1997;23:243–246
  8. Lapeyre M, Hoffstetter S, Peiffert D, et al. Postoperative brachytherapy alone for T1-2 N0 squamous cell carcinomas of the oral tongue and floor of mouth with close or positive margins. Int J Radiat Oncol Biol Phys. 2000;48:37–42
  9. Zelefsky MJ, Zimberg SH, Raben A, et al. Brachytherapy for locally advanced and recurrent lymph node metastases. J Brachytherapy Int. 1998;14:123–130
  10. Kupferman ME, Morrison WH, Santillan AA, et al. The role of interstitial brachytherapy with salvage surgery for the management of recurrent head and neck cancers. Cancer. 2007;109:2052–2057
  11. Martinez-Monge R, Alcalde J, Concejo C, et al. Perioperative high-dose-rate brachytherapy (PHDRB) in previously irradiated head and neck cancer: initial results of a Phase I/II reirradiation study. Brachytherapy. 2006;5:32–40
  12. Park RI, Liberman FZ, Lee DJ, et al. Iodine-125 seed implantation as an adjunct to surgery in advanced recurrent squamous cell cancer of the head and neck. Laryngoscope. 1991;101:405–410
  13. Nutting C, Horlock N, A'Hern R, et al. Manually after-loaded 192Ir low-dose rate brachytherapy after subtotal excision and flap reconstruction of recurrent cervical lymphadenopathy from head and neck cancer. Radiother Oncol. 2006;80:39–42
  14. Narayana A, Cohen GN, Zaider M, et al. High-dose-rate interstitial brachytherapy in recurrent and previously irradiated head and neck cancers–preliminary results. Brachytherapy. 2007;6:157–163
  15. Pellizzon AC, Salvajoli JV, Kowalski LP, et al. Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy. Radiat Oncol. 2006;1:27
  16. Ang KK, Trotti A, Brown BW, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51:571–578
  17. International Commission on Radiation Units and Measurements . Dose and volume specification for reporting interstitial therapy. ICRU Report 58 Bethesda, MD: International Commission on Radiation Units and Measurements; 1997;
  18. Douglas BG, Fowler JF. The effect of multiple small doses of x rays on skin reactions in the mouse and a basic interpretation. Radiat Res. 1976;66:401–426
  19. Nag S, Martinez-Monge R, Zhang H, et al. Simplified non-looping functional loop technique for HDR brachytherapy. Radiother Oncol. 1998;48:339–341
  20. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Asoc. 1958;53:457–481
  21. Melzner WJ, Lotter M, Sauer R, et al. Quality of interstitial PDR-brachytherapy-implants of head-and-neck-cancers: predictive factors for local control and late toxicity?. Radiother Oncol. 2007;82:167–173

PII: S1538-4721(08)00649-1

doi: 10.1016/j.brachy.2008.10.002

Brachytherapy
Volume 8, Issue 1 , Pages 26-33 , January 2009

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