Brachytherapy
Volume 6, Issue 4 , Pages 286-292 , October 2007

Long-term outcome and toxicity in a Phase I/II trial using high-dose-rate multicatheter interstitial brachytherapy for T1/T2 breast cancer

  • Seth A. Kaufman

      Affiliations

    • Department of Radiation Oncology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA
    • ,
  • Thomas A. DiPetrillo

      Affiliations

    • Department of Radiation Oncology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA
    • Department of Radiation Oncology, Rhode Island Hospital, Brown University School of Medicine, Providence, RI
    • ,
  • Lori Lyn Price

      Affiliations

    • Department of Clinical Care Research, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA
    • ,
  • Jennifer Bassett Midle

      Affiliations

    • Department of Clinical Care Research, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA
    • ,
  • David E. Wazer

      Affiliations

    • Department of Radiation Oncology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA
    • Department of Radiation Oncology, Rhode Island Hospital, Brown University School of Medicine, Providence, RI
    • Corresponding Author InformationCorresponding author. Department of Radiation Oncology, Box 359, Tufts-New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111. Tel.: +1-617-636-6161; fax: +1-617-636-6131.

Received 13 March 2007 ,Revised 1 September 2007 ,Accepted 10 September 2007.

References 

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  2. Wazer DE, Berle L, Graham R, et al. Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys. 2002;53:889–897
  3. Wazer DE, Lowther D, Boyle T, et al. Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2001;50:107–111
  4. Wazer DE, Kaufman S, Cuttino L, et al. Accelerated partial breast irradiation: An analysis of variables associated with late toxicity and long-term cosmetic outcome after high-dose-rate interstitial brachytherapy. Int J Radiat Oncol Biol Phys. 2006;64:489–495
  5. Wazer DE, DiPetrillo TA, Schmidt-Ullrich RK, et al. Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early stage breast carcinoma. J Clin Oncol. 1992;10:356–363
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  9. Kuske RR, Winter K, Arthur DW, et al. A phase II trial of brachytherapy alone following lumpectomy for stage I and II breast cancer: Initial outcomes of RTOG 9517. J Clin Oncol. 2004;22(14S):565
  10. Krishnan L, Jewell WR, Tawfik OW, et al. Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer. Breast J. 2001;7:91–96
  11. Cionini L, Pacini P, Marzano S, et al. Exclusive brachytherapy after conservative surgery in cancer of the breast. [Abstract] Lyon Chir. 1993;89:128
  12. Lawenda BD, Taghian AG, Kachnic LA, et al. Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implant. Int J Radiat Oncol Biol Phys. 2003;56:671–680
  13. Das RK, Patel R, Shah H, et al. 3D CT-based high-dose-rate breast brachytherapy implants: Treatment planning and quality assurance. Int J Radiat Oncol Biol Phys. 2004;59:1224–1228
  14. Fentiman IS, Poole C, Tong D, et al. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer. 1996;32A:608–611
  15. Fentimen IS, Deshmane V, Tong D, et al. Caesium137 implant as sole radiation therapy for operable breast cancer: A phase II trial. Radiother Oncol. 2004;71:281–285
  16. Perera F, Yu E, Engel J, et al. Patterns of breast recurrence in a pilot study of brachytherapy confined to the lumpectomy site for early breast cancer with six years' minimum follow-up. Int J Radiat Oncol Biol Phys. 2003;57:1239–1246
  17. Polgar C, Major T, Fodor J, et al. High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast-conserving surgery: Seven-year results of a comparative study. Int J Radiat Oncol Biol Phys. 2004;60:1173–1181
  18. Polgar C, Strnad V, Major T. Brachytherapy for partial breast Irradiation: The European experience. Semin Radiat Oncol. 2005;15:116–122

 Presented in oral form at the 27th Annual Meeting of the American Brachytherapy Society, Philadelphia, PA, 2006.

PII: S1538-4721(07)00250-4

doi: 10.1016/j.brachy.2007.09.001

Brachytherapy
Volume 6, Issue 4 , Pages 286-292 , October 2007

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