Brachytherapy
Volume 6, Issue 3 , Pages 218-226 , July 2007

Clinical outcome after treatment with a brachytherapy boost versus external beam boost for anal carcinoma

  • Christoph Oehler-Jänne

      Affiliations

    • Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
  • ,
  • Burkhardt Seifert

      Affiliations

    • The Center for Biostatistics, University of Zurich, Zurich, Switzerland
  • ,
  • Urs M. Lütolf

      Affiliations

    • Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
  • ,
  • Gabriela Studer

      Affiliations

    • Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
  • ,
  • Christoph Glanzmann

      Affiliations

    • Radiation Oncology, Zurich University Hospital, Zurich, Switzerland
  • ,
  • I. Frank Ciernik

      Affiliations

    • The Center for Clinical Research, Zurich University Hospital, Zurich, Switzerland
    • The Oncology Institute of Southern Switzerland, Ospedale San Giovanni e Valli, Bellinzona, Switzerland
    • Corresponding Author InformationCorresponding author. Radiation Oncology, Istituto Oncologico della Svizzera Italiana, Ospedale SanGiovanni e Valli, 6500 Bellinzona, TI, Switzerland. Tel.: +41-91-811-9157; fax: +41-91-811-8678.

Received 3 August 2006 ,Revised 30 January 2007 ,Accepted 16 February 2007.

References 

  1. Ortholan C, Ramaioli A, Peiffert D, et al. Anal canal carcinoma: Early-stage tumors < or =10 mm (T1 or Tis): Therapeutic options and original pattern of local failure after radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:479–485
  2. Chauveinc L, Buthaud X, Falcou MC, et al. Anal canal cancer treatment: Practical limitations of routine prescription of concurrent chemotherapy and radiotherapy. Br J Cancer. 2003;89:2057–2061
  3. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: Results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol. 1997;15:2040–2049
  4. Flam M, John M, Pajak TF, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: Results of a phase III randomized intergroup study. J Clin Oncol. 1996;14:2527–2539
  5. Gerard JP, Ayzac L, Hun D, et al. Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil–cisplatinum. Long-term results in 95 patients. Radiother Oncol. 1998;46:249–256
  6. Doci R, Zucali R, Bombelli L, et al. Combined chemoradiation therapy for anal cancer. A report of 56 cases. Ann Surg. 1992;215:150–156
  7. John M, Flam M, Palma N. Ten-year results of chemoradiation for anal cancer: Focus on late morbidity. Int J Radiat Oncol Biol Phys. 1996;34:65–69
  8. Papillon J, Montbarbon JF. Epidermoid carcinoma of the anal canal. A series of 276 cases. Dis Colon Rectum. 1987;30:324–333
  9. Papillon J, Montbarbon JF, Gerard JP, et al. Interstitial curietherapy in the conservative treatment of anal and rectal cancers. Int J Radiat Oncol Biol Phys. 1989;17:1161–1169
  10. Pizzi GB, Marchetti C. Brachytherapy with pulsed dosage. General considerations. Radiobiological considerations. First clinical experience in Mestre (Venice), Radiol Med (Torino). 1997;93:260–266
  11. Kapp KS, Geyer E, Gebhart FH, et al. Experience with split-course external beam irradiation +/− chemotherapy and integrated Ir-192 high-dose-rate brachytherapy in the treatment of primary carcinomas of the anal canal. Int J Radiat Oncol Biol Phys. 2001;49:997–1005
  12. Vordermark D, Flentje M, Sailer M, et al. Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life. Strahlenther Onkol. 2001;177:252–258
  13. Sandhu AP, Symonds RP, Robertson AG, et al. Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: Ten years experience. Int J Radiat Oncol Biol Phys. 1998;40:575–581
  14. Hwang JM, Rao AR, Cosmatos HA, et al. Treatment of T3 and T4 anal carcinoma with combined chemoradiation and interstitial 192Ir implantation: A 10-year experience. Brachytherapy. 2004;3:95–100
  15. Dubois JB, Azria D, Ychou M. External beam radiation therapy and interstitial brachytherapy in the treatment of anal canal carcinomas: A series of 70 patients, Bull Cancer. 2003;90:1107–1110
  16. Peiffert D, Bey P, Pernot M, et al. Conservative treatment by irradiation of epidermoid carcinomas of the anal margin. Int J Radiat Oncol Biol Phys. 1997;39:57–66
  17. Myerson RJ, Kong F, Birnbaum EH, et al. Radiation therapy for epidermoid carcinoma of the anal canal, clinical and treatment factors associated with outcome. Radiother Oncol. 2001;61:15–22
  18. Papillon J, Montbarbon JF, Gerard JP, et al. Radionecrosis after curietherapy for anal carcinoma. Current methods of radiation therapy (author's transl), Gastroenterol Clin Biol. 1979;3:193–198
  19. Allal AS, Sprangers MA, Laurencet F, et al. Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy. Br J Cancer. 1999;80:1588–1594
  20. Broens P, Van Limbergen E, Penninckx F, et al. Clinical and manometric effects of combined external beam irradiation and brachytherapy for anal cancer. Int J Colorectal Dis. 1998;13:68–72
  21. Vordermark D, Sailer M, Flentje M, et al. Curative-intent radiation therapy in anal carcinoma: Quality of life and sphincter function. Radiother Oncol. 1999;52:239–243
  22. Allal AS, Mermillod B, Roth AD, et al. Impact of clinical and therapeutic factors on major late complications after radiotherapy with or without concomitant chemotherapy for anal carcinoma. Int J Radiat Oncol Biol Phys. 1997;39:1099–1105
  23. Milano MT, Jani AB, Farrey KJ, et al. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: Toxicity and clinical outcome. Int J Radiat Oncol Biol Phys. 2005;63:354–361
  24. Oehler-Janne C, Seifert B, Lutolf UM, et al. Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy. Radiat Oncol. 2006;1:29
  25. Trotti A, Colevas AD, Setser A, et al. CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003;13:176–181
  26. Williams J, Chen Y, Rubin P, et al. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 2003;13:182–188
  27. Berger C, Felix-Faure C, Chauvet B, et al. Conservative treatment of anal canal carcinoma with external radiotherapy and interstitial brachytherapy, with or without chemotherapy: Long-term results, Cancer Radiother. 1999;3:461–467
  28. Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research. Lancet. 1996;348:1049–1054
  29. Cummings BJ, Keane TJ, O'Sullivan B, et al. Epidermoid anal cancer: Treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Radiat Oncol Biol Phys. 1991;21:1115–1125
  30. Papillon J. Rectal and anal cancers. Heidelberg: Springer Verlag; 1982;

PII: S1538-4721(07)00214-0

doi: 10.1016/j.brachy.2007.02.152

Brachytherapy
Volume 6, Issue 3 , Pages 218-226 , July 2007