Brachytherapy
Volume 6, Issue 1 , Pages 53-57 , January 2007

Adjuvant high-dose-rate and low-dose-rate brachytherapy with external beam radiation in soft tissue sarcoma: A comparison of outcomes

  • Surjeet Pohar

      Affiliations

    • Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY
    • Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, VA
    • Corresponding Author InformationCorresponding author. Department of Radiation Oncology, Eastern Virginia Medical School, 600 Gresham Drive, Norfolk, VA 23507. Tel.: +1-757-388-2075; fax: +1-757-627-0334.
    • ,
  • Rashid Haq

      Affiliations

    • Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY
    • ,
  • Lizhong Liu

      Affiliations

    • Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY
    • ,
  • Michael Koniarczyk

      Affiliations

    • Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY
    • ,
  • Seung Hahn

      Affiliations

    • Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY
    • ,
  • Timothy Damron

      Affiliations

    • Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY
    • ,
  • Jesse N. Aronowitz

      Affiliations

    • Department of Radiation Oncology, University of Massachusetts, Worcester, MA

Received 25 September 2006 ,Revised 1 November 2006 ,Accepted 3 November 2006.

References 

  1. Lawrence W, Baker LH, Balch CM, et al. Limb-sparing treatment of adult soft-tissue sarcoma and osteosarcomas. JAMA. 1985;254:1791–1794
  2. Lindberg RD, Martin RG, Romsdahl MM. Surgery and postoperative radiotherapy in the treatment of soft tissue sarcomas in adults. Am J Roentgenol Radium Ther Nucl Med. 1975;123:123–129
  3. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft tissue sarcomas of the extremities. Ann Surg. 1982;196:305–315
  4. Brennan MF, Hilaris B, Shiu MH, et al. Local recurrence in adult soft tissue sarcoma: A randomized trial of brachytherapy. Arch Surg. 1987;122:1289–1293
  5. Alekhteyar KM, Leung DH, Brennan MF, et al. The effect of combined external beam radiotherapy and brachytherapy on local control and wound complications in patients with high-grade soft tissue sarcomas of the extremity with positive microscopic margin. Int J Radiat Oncol Biol Phys. 1996;36:321–324
  6. Andrews SF, Anderson PR, Eisenberg BL, et al. Soft tissue sarcomas treated without postoperative external beam RT with and without low-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys. 2004;59:475–480
  7. Delannes M, Thomas L, Martel P, et al. Low-dose-rate intraoperative brachytherapy combined with external beam irradiation in the conservative treatment of soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2000;47:165–169
  8. Martinez-Monge R, Julian MS, Amillo S, et al. Perioperative high dose rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: Initial results of a pilot study. Brachytherapy. 2005;4:264–270
  9. Holt GE, Griffin AM, Pintilie M, et al. Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2005;87:315–319
  10. Lin PP, Schupak KD, Boland PJ, et al. Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer. 1998;82:2356–2365
  11. Alekhtayer KM, Porter AT, Ryan J, et al. Preliminary results of high dose rate brachytherapy in soft tissue sarcoma. Endocuriether Hypotherm Oncol. 1993;9:56
  12. Crownover RL, Marks KE, Zehr RJ, et al. Initial results with high dose-rate brachytherapy for soft tissue sarcomas. Sarcoma. 1997;1:96
  13. Koizumi M, Inoue T, Yamazaki H, et al. Perioperative fractionated high-dose rate brachytherapy for malignant bone and soft tissue tumors. Int J Radiat Oncol Biol Phys. 1999;43:989–993
  14. Chun M, Kang S, Kim BS, et al. High dose rate interstitial brachytherapy in soft tissue sarcoma: Technical aspects and results. Jpn J Clin Oncol. 2001;31:279–283
  15. Donath D, Janjan N, Harrison LB. Soft tissue sarcomas. In:  Nag S editors. Principles and practice of brachytherapy. Armonk, NY: Futura Publishing; 1997;p. 585–596
  16. Petera J, Neumanova R, Odrazka K, et al. Perioperative fractionated high-dose rate brachytherapy in the treatment of soft tissue sarcomas. Neoplasma. 2004;51:59–63
  17. Aronowitz JA, Pohar S, Liu L, et al. Adjuvant high dose rate brachytherapy in soft tissue sarcomas: A dose toxicity analysis. Am J Clin Oncol. 2006;29:508–513
  18. Greene FL, Page DL, Fleming ID, et al. eds. AJCC cancer staging manual. 6th ed; 2002.
  19. Common terminology criteria for adverse events (CTCAE 3.0). Available at: http://ctep.cancer.gov/forms/CTCAEv3.pdf, August 2006.
  20. Hall EJ. Radiobiology for the radiobiologist. 4th ed.. Philadelphia, PA: J.B. Lippincott Company; 1994;
  21. Ling CL, Roy JN. Radiobiophysical aspects of brachytherapy. In:  Williamson JF,  Thomadsen BR,  Nath R editor. Brachytherapy physics. Madison, WI: Medical Physics Publishing Corp.; 1994;p. 42–43
  22. Saddegh MK, Bauer HC. Wound complications in surgery of soft tissue sarcoma: Analysis of 103 consecutive patients managed without adjuvant therapy. Clin Orthop Relat Res. 1993;289:247–253
  23. Skibber JM, Lotze MT, Seipp CA, et al. Limb sparing surgery for soft tissue sarcoma: Wound related morbidity in patients undergoing wide local excision. Surgery. 1987;102:447–452
  24. Bujko K, Suit HD, Springfield DS, et al. Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gynecol Obstet. 1993;176:124–134
  25. O'Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: A randomized trial. Lancet. 2002;359:2235–2241
  26. Davis AM, O'Sullivan B, Turcotte R, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75:48–53
  27. Simon J, Mazeron JJ, Pohar S, et al. Effect of intersource spacing on local control and complications in brachytherapy of mobile tongue and floor of mouth. Radiother Oncol. 1993;26:19–25
  28. Kuske R, Winter K, Arthur D, et al. A phase II trial of brachytherapy alone following lumpectomy for select breast cancer: Toxicity analysis of Radiation Therapy Oncology Group 95-17. Int J Radiat Oncol Biol Phys. 2002;54:87

 Presented at the 47th ASTRO Annual Meeting, October 2005, Denver, CO.

PII: S1538-4721(06)00301-1

doi: 10.1016/j.brachy.2006.11.004

Brachytherapy
Volume 6, Issue 1 , Pages 53-57 , January 2007

Article Tools

* Image Usage & Resolution